ECTRIMS 2021 – Late Breaking News ePoster
نویسندگان
چکیده
Objective: To compare humoral and T-cell responses to COVID- 19 vaccines in 400 MS patients who were on Ocrelizumab ('OCR') v. other disease-modifying therapies ('non-OCR') at the time of vaccination. Introduction: Peripheral B-cell depletion with anti-CD20 attenuates vaccines. Whether immune COVID-19 differ between depleted non-B cell is not known. Methods: Consecutive from NYU Care Center invited participate if they completed vaccination ?6 weeks previously. Immune testing included anti-spike RBD antibody (Elecsys Anti-SARS-CoV-2) (Roche Diagnostics);multiplex bead-based immunoassays antibody-responses SARS-COV-2 spike proteins;T-cell SARS-CoV-2 Spike protein using IFN? enzyme-linked immune-absorbent spot (Invitrogen) TruCulture (Myriad RBM) assays;high dimensional immunophenotyping;and live virus immunofluorescencebased microneutralization assay. Results: As 7/15/2021, 105 subjects enrolled (mean age: 40.5 years;76% female;41% non-white;38% OCR;12% prior infection). 95% fully vaccinated mRNA (Pfizer/Moderna);5% - adenovirus-based vaccine (JohnsonJp<0.0001). Positive response by multiplex assay (threshold 'positive' defined as 2 SD below mean for non-OCR) detected 10/27 (37%) OCR 29/31 (94%) non-OCR (p<0.00001). activation based induced secretion (TruCulture) was 20/25 (80%) 16/19 (84%) (p=0.71). Conclusions: Preliminary results suggest robust SARS-CoV2 approximately 80% both patients. Antibody markedly attenuated compared group. Updated will be presented.
منابع مشابه
Late-breaking News
It has been quite a while since I’ve written one of these columns. Our production team (whose names may be found on the back of the title page) has grown to include some new members. Most notable of these has been Karl Berry, who has provided technical input, editorial input, as well as having gone out and “beat the bushes” to obtain new and interesting articles. The major problem over the past...
متن کامل“Breaking news” from spermatids
During the haploid phase of spermatogenesis, spermatids undergo a complex remodeling of the paternal genome involving the finely orchestrated replacement of histones by the highly-basic protamines. The associated striking change in DNA topology is characterized by a transient surge of both single- and double-stranded DNA breaks in the whole population of spermatids which are repaired before spe...
متن کاملBreaking Bad News
Even the most skilled physician knows that conveying bad news to a patient or family can be one of the most arduous aspects of health care. Historically, breaking bad news is a skill that has generally been under-emphasized in training programmes. Critical care physicians are commonly faced with the difficult task of breaking bad news, often in dramatic, emotional and unexpected situations. Bre...
متن کاملBreaking bad news concerning fertility.
Introduction The subject for this opinion paper is breaking bad news, a complex and integral part in the area of infertility. From the couple’s point of view, involuntary childlessness is not a question of once receiving bad news but repeatedly receiving bad news during the infertility investigation and treatment. Already before seeking medical attention, the couple will have had monthly bad ne...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Multiple Sclerosis Journal
سال: 2021
ISSN: ['1352-4585', '1477-0970']
DOI: https://doi.org/10.1177/13524585211047080